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Although supplementation with these amino acids can stimulate protein anabolism, it is important to recognize that certain amino acids may also exacerbate cachexia by modulating inflammation, immunity, and energy metabolism

The AAAH are all homotetramers, with each subunit consisting of a catalytic domain which has high homology (sequence identity over 80%) and a regulatory domain which is divergent (Hufton et al., 1995)