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While the goal is to treat patients before the development of acute liver failure, treatment should still be given to patients who are found to be in active hepatic failure since NAC appears to improve hepatic perfusion and oxygen delivery, to refine mitochondrial energy metabolism, and to facilitate scavenging of reactive oxygen and nitrogen species.56,6062 NAC can be delivered as either intravenous (IV) or oral (PO) preparations, with dosing based on the patients body weight (maximum dose of 110 kg for oral and 100 kg for IV).54,56,71 The standard formulations for NAC are as follows

Consumo consigliato Assumere 2-4 capsule al giorno durante un pasto con sufficiente liquido

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The molecular components of DNA repair pathway(s) are described in Chapter 5, Section 5.3

Pharmacokinetics of rectal paracetamol after repeated dosing in children