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Traditional cancer cell models have been extensively used in high-throughput drug screening assays

Arsenic has been proposed to induce cell death through thioredoxin reductase (TrxR) inhibition, with both N-terminal dithiols and C-terminal selenothiol interacting with arsenic compound [54]

(Sharma et al., 2016)

ICTR 2006

Rather these reactions exhibit a significant degree of selectivity in accordance with the Hard and Soft, Acids and Bases (HSAB) theory of Pearson, which states that electrophiles preferentially and more rapidly form covalent bonds with nucleophiles of comparable softness or hardness

Li J, Meng L, Ren S, Jia C, Liu R, Jiang H, Chen J