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Various causes, including exogenous and endogenous stress factors, an imbalance between prooxidants and antioxidants, disruption of antioxidant pathways, and gene polymorphisms, lead to the overproduction of reactive oxygen species

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Elevated ROS injure cells by promoting degradation of cellular proteins, lipids and DNA, subvert beta cell biosynthetic capacity and cause endoplasmic reticulum (ER) stress or entwine with it (Hasnain et al

Thus, it is unlikely that the activity of catechol sideromycins against NTHi will be greater than that of the antibiotic alone

Increased overall survival was associated with the T allele (De las Peas et al., 2012) have shown inverse results (Ren et al., 2012) including a large number of patient ( n = 340) with NSCLC

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