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In cervical cancer (HeLa) cells, apigenin induce apoptosis via two distinct pathways: one involves down-regulating Bcl-2 protein expression, while the other activates p53 to varying degrees, leading to the induction of p21, fatty acid synthase (Fas) expression and ultimately apoptosis [80]

Integrins: Bidirectional, allosteric signaling machines

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Varied Results: Effectiveness varies from one individual to another due to genetics, dosage, and formulation (oral, topical, or injectable)