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The adrenal glands generate hormones such as glucocorticoids, mineralocorticoids, and androgens, ( Figure 1 ) which play significant roles in regulating various physiological processes (55)

Neuroprogression Each of these processes all affects each other which can lead to an escalation of problems over time

Analysis of a cohort of 874 patients who underwent lumbar spinal fusion found that at 24 months post-surgery, an alarming 44.4% of patients had been prescribed opioids for continued pain management and 37.8% of patients were receiving mental health treatment for stresses related surgery and back pain (McMillan et al., 2021)

On the other hand, sedentary behavior and a lack of exercise can decrease glutathione levels

Allegra, M