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Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Similarly, in lung fibrosis, inhibition of the Nrf2 pathway is closely associated with elevated levels of oxidative stress in fibrotic tissues, which in turn triggers the abnormal deposition of fibrous components such as collagen, leading to a post-ferroptotic state in lung tissue cells [8, 9]

Giroud-Gerbetant, J

Mild oxidative stress reduces NRF2 SUMOylation to promote kras/Lkb1/Keap1 mutant lung adenocarcinoma cell migration and invasion

Prog Mol Biol Transl Sci 112:3188

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