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10.1038/cti.2016.17 364

An animal study in a reserpine-induced fibromyalgia rat model found that nano-pregabalin (N-PG) alleviated FM symptoms by enhancing CNS penetration, restoring neurotransmitter balance (Glut, NE, CGRP), increasing antioxidant enzyme activity (e.g., SOD), inhibiting pro-inflammatory transcription factors (e.g., NF-B), and reducing apoptosis by decreasing caspase-3 (Casp-3) activation (36)

Neural crest cells (NCCs) are vital in vertebrate embryonic development, and their behavior is linked to nervous system defects

In smokers, the levels of inflammatory cytokines such as TNF- and IL-6 are elevated, which stimulates osteoclast activity and accelerates bone resorption 26,27