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The reason the who should avoid list is framed so broadly is not boilerplate caution

doi: 10.1038/s41467-023-40635-w 203 OrtolaniO.ContiA.De GaudioA

Interferon-alpha and -beta inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14(+) precursors

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In this process, multiple mechanisms, such as oxidative stress, mitochondrial dysfunction, and neuroinflammation, act synergistically, forming a vicious cycle

63,64 Ultimately, through regulation at the tissue and organ levels, these processes influence the onset and progression of diseases in the organism