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Translation of promising preclinical findings into clinical applications is crucial, as many studies have failed to demonstrate efficacy in clinical trials [123]

Since then, dozens of clinical studies have been published with this ingredient

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Regarding citric acid cycle dysfunction, it seems that the formation deficiency of succinyl-CoA, a precursor to succinate, and -ketoglutarate may be involved with the mechanism (Fig

Taken together, our structural data provides evidence for sequential co-translational methionine excision and N-myristoylation executed via consecutive binding of the respective enzymes