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The HGF/c-Met pathway mediates downstream signaling through Ras/Raf/MAPK, PI3K/AKT/mTOR, and/or STAT3/5 pathways [58]

Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats

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It is possible that ER stress induced by enhanced metabolic activity might prime the ER by eliciting prophylactic ER stress

doi:10.1038/ni.3711

A promising avenue involves the utilization of cysteine-rich protein-based tactics targeting cysteine-rich angiogenic inducer 61 (CCN1/CYR61) (123), which could potentially mitigate the biological aggressiveness of TNBC or BLBC