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Preclinical and clinical studies have demonstrated its efficacy in reducing body weight both as a monotherapy and in combination with GLP-1 receptor agonists such as semaglutide, highlighting its potential as a next-generation therapeutic agent for obesity and metabolic syndrome management

This may help manage nerve-related discomfort and support overall neurological health

The positive association between serum B12 and mortality risk might stem from compensatory elevation of B12 levels in response to impaired B12 sensitivity

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Conclusion Synchronous bariatric surgery and complex ventral hernia repair should be approached in high-volume centres where a consolidated experience of multidisciplinary teamwork is available

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