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Cobalamin should be supplemented whenever serum cobalamin concentration is in the low normal range (i.e., less than approximately 400 ng/L) in both dogs and cats

Also, there was no interaction detected between predictor variables in either model

We bring the same rigor to nutrient therapy that we apply across our practice, testing first, dosing to the individual, and rechecking over time

Disclosures: Brett McGettigan: Nothing to Disclose, Dawood Al Dawood: Nothing to Disclose, Harmeet Malhi: MERCK: Consultant, Vijay Shah: Boehringer Ingelheim: Consultant, GSK: Consultant, GENFIT SA: Consultant, Intercept Pharmaceuticals, Inc.: Advisor, Korro Bio, Inc.: Consultant, Mallinckrodt Pharmaceuticals: Advisor, Novo Nordisk A/S: Consultant, Resolution Therapeutics, Ltd.: Advisor, Seal Rock Therapeutics, Ltd.: Consultant, Surrozen: Advisor 1569 HEPATIC METHYLTRANSFERASE PROTEINS MEDIATE PNPLA3-I148M-DRIVEN LIPID DROPLET DYNAMICS IN FATTY LIVER Xinshou Ouyang 1 Yan Zhang 2 Suyavaran ARUMUGAM 2 Shi-Ying Cai 1 Wanqing Liu 3 Wajahat Mehal 1 , 1 Yale University, 2 Yale School of Medicine, 3 Wayne State University Background: The accumulation of Lipid droplets (LDs) characterizes fatty liver in metabolic dysfunction-associated fatty liver disease (MAFLD) and alcohol-associated liver disease (ALD), closely tied to genetic variants, particularly PNPLA3 -I148M