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[20] A seventh article was an extensive review of biochemical mechanisms of how GSH causes depigmentation in cell cultures and laboratory animals

consequently, the fitness cost associated with its mutation might be lower, making it a clinically significant resistance mechanism (Pipitone et al., 2023)

doi: 10.1016/j.isci.2023.107487 126 ChoiSLiWZhangXKandaNLeilaniZTengXet al

Nrf2, which can induce the expression of phase II detoxifying enzyme-encoding genes through antioxidant response elements (AREs), was defined as a master regulator of antioxidant systems in 1997

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