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While human studies of asthma are not available, these findings suggest that glutaredoxin1 inhibition may play an important role in asthma-related oxidative stress and airway structural changes given its suppression by TGF1

Physiol Rev 1997 Jan

Sustained inflammatory insults induce cumulative DNA damage and epigenetic reprogramming, fostering malignant transformation through two synergistic mechanisms: (1) persistent immune cell activation (neutrophils, macrophages, lymphocytes) and (2) tumor co-option of inflammatory mediators (IL-6, TNF-, COX-2) as metastatic accelerants