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The identification of HIF2 by independent groups in 1997 (initially called endothelial PAS protein 1 (EPAS1) 8 , HIF-related factor (HRF) 9 , HIF1-like factor (HLF) 10 , and member of PAS family 2 (MOP2) 11 ) indicated that HIF regulation was more complex

Several factors may contribute, including dietary choices, certain medical conditions, and even age

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Therefore, the lack of nutrients itself may not account for the immunosuppressive function of IDO in vivo [281, 282]

Acknowledgments We thank the Fondazione per la ricerca sulla Fibrosi Cistica - Onlus for its grant (FFC#20/2018)

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