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We also describe various applications and advantages of this Cys-targeted proteomics method and alternative approaches to overcome potential limitations of this method in studying oxidized proteins from MDMA-exposed tissues

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Furthermore, to robustly quantify the transcriptomic similarity between tumor cells and myeloid cells, we calculated at single cell resolution multiple metrics, including Manhattan and Euclidean distance metrics, the Cosine and Pearson correlation-based directional similarity metrics, as well as the Phi and Bray-Curtis proportionality and compositional dissimilarity metrics 22,23

10.1021/acsnano.2c09593 42 HuangL.LiuG

Ultimately, these factors create a vicious cycle that contributes to HF