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In vivo , the use of MK-801 was sufficient to inhibit cell proliferation at a level comparable to that observed in vitro , however, although the use of MK-801 in vivo could reduce the invasion of cells, the reduction was not as striking as in vitro

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An evenly thickened skin area (about 2 cm 2 cm) was selected and topically applied with PBS suspension containing [email protected] or free Cy5.5 (1 g per mouse)