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Factors such as the severity of the deficiency, the body's rate of usage, and individual metabolic differences all play a role

Raimondo, stating that courts [must] use every tool at their disposal to determine the best reading of the statute. [293] The commenter argued that CMS failed to adopt the best reading of the statutory requirement for the discarded drug refund, contending that its interpretation unfairly penalizes manufacturers with refundable drugs available on the market when the regulations took effect, despite regulatory decisions being made in compliance with laws prior to the enactment of section 90004 of the Infrastructure Act

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(5) evaluate the potential impact of pre-hospital transfusion programs on the hospitals' inventories, which are essential to patient care