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As trophoblasts undergo differentiation into their lineages, they undergo an epithelial-mesenchymal transition (EMT)-like process and cell-cell fusion, akin to processes observed in cancer

NNMT (nicotinamide N-methyltransferase) catalyses transfer of a methyl group from S-adenosylmethionine to nicotinamide

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With the youngest of their number being 17 (forever), the Cullens could easily have avoided detection for longer by graduating high school and not attending the institution thereafter