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Adjacent lysosomes recognize and engulf these protrusions [141]

A key aspect of this crosstalk is the livers secretion of hepatokines, such as fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15), which increase insulin sensitivity, 191 promote mitochondrial integrity in cardiomyocytes via the AMPK/FOXO3/SIRT3 signaling axis, 192 and suppress renal fibrosis