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The detection of methylated circulating tumor DNA (ctDNA) of SEPT9 in blood is used as a screening method for colorectal cancer (CRC) (Laven-Law et al., 2024)

FDA approved anti-angiogenic agents Upon successful preclinical studies (Table 1), a myriad of clinical trials have been accomplished or are ongoing to determine the safety, feasibility, and efficacy of anti-angiogenic agents therapy in cancer patients alone or in combination with other therapeutic means (Table 2)

Key Safety Differentiators No IGF-1 elevation: AOD-9604 does not stimulate IGF-1, meaning it avoids risks such as organ/tissue overgrowth or acromegaly No glucose disruption: Clinical data shows it does not impair insulin sensitivity or worsen blood sugar regulation Comparable to placebo: In obesity trials, the incidence of adverse effects was similar to placebo groups, underscoring its tolerability Legal Status of AOD-9604 United States: AOD-9604 is not FDA-approved as a drug, dietary supplement, or weight loss therapy

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Res Synth Methods 3

M., Satylganova, A., & ONeil, P