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The brains heightened vulnerability to oxidative stress is intimately linked with the previous findings on locomotor activity

This NRF2 GCLC interaction means that NFE2L2 genetic variants that reduce NRF2 activity compound GCLC promoter variant effects reducing both baseline expression and stress-induced GCLC upregulation simultaneously

Das S, Dewanjee S, Dua TK et al (2019) Carnosic acid attenuates cadmium induced nephrotoxicity by inhibiting oxidative stress, promoting Nrf2/HO-1 signalling and impairing TGF-1/Smad/collagen IV signalling

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Antioxidants stabilize free radicals by donating electrons, effectively neutralizing their reactivity without becoming unstable themselves

(2004) who used this cell culture as a model to explore plant metabolism of explosives in the past