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Visible light excitable fluorescence probe and its functionalized Merrifield polymer: Selective sensing and removal of arsenate from real samples

PMC 2784456

The advantages and prospective therapeutic benefits are manifested through: 1) Targeted modulation of oxidative stress mechanisms: through inhibiting SLC7A11, levels of reactive oxygen species (ROS) can be heightened, leading to the selective demise of tumor cells dependent on antioxidant mechanisms ( 2) Augmented effectiveness of combination therapies: For instance, the pairing of MLN4924 (a CRL3 inhibitor) with the ferroptosis inducer IKE can collaboratively suppress tumor proliferation by stabilizing SLC7A11 while concurrently obstructing its function ( 3) Reversal of the immunosuppressive tumor milieu: In lung adenocarcinoma, diminished expression of SLC7A11 correlates with heightened infiltration of CD8 + T cells, implying that its inhibition could bolster responses to immunotherapeutic approaches ( In conclusion, the intricacy of SLC7A11 in cell death is attributable to its regulation of oxidative stress, ferroptosis and multi-pathway interactions, which offers avenues for multifaceted intervention and numerous entry points

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