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OU749 is an uncompetitive inhibitor with a K i of 17 uM [76], while GGsTop is a mechanism-based irreversible inhibitor, with an active ester of phosphonate mimicking the transition state of GSH in the GGT pocket, whose k inact /K I is 57 M 1 s 1 [77]

Fitoterapia 78:590592

Reactive oxygen species (ROS) or free radicals cause damage to key cellular components like DNA, RNA, lipids, proteins, and structural membranes

In the cellular context, these aberrant interactions can disrupt physiological processes by sequestering various proteins essential for normal cellular functions, resulting in diffused aggregates that may act as molecular triggers for LB nucleation

Al Jasem Y, Khan M, Taha A, Thiemann T

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