glutathione peroxidase 4 a new player in neurodegeneration

glutathione peroxidase 4 a new player in neurodegeneration (GPX4) | Expert tips Glutathione peroxidase 4‐dependent glutathione high‐consumption

Name: glutathione peroxidase 4 a new player in neurodegeneration (GPX4) | Expert tips Glutathione peroxidase 4‐dependent glutathione high‐consumption
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Glutathione peroxidase 4dependent glutathione highconsumption drives acquired platinum chemoresistance in lung cancerderived brain metastasis Liu 2021 Clinical and Translational Medicine Wiley Online Library Molecular Medicine Reports Frontiers Insight into the potential role of ferroptosis in neurodegenerative diseases What Is the Role of Ferroptosis in Neurodegeneration? Neurology Frontiers Activation of Glutathione Peroxidase 4 as a Novel Anti inflammatory Strategy Frontiers Ferroptosis in neurodegenerative diseases: potential mechanisms of exercise intervention

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doi:10.3390/ijms24087289

Excessive glutamate release activates NMDARs and AMPARs, leading to Ca 2+ overload, promoting neuronal oxidative stress, inducing mitochondrial damage, and increasing the risk of cell death