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Clinical Progress of Glutaminase Inhibitors Glutaminase inhibitors selectively target the overactive GLS in cancer cells, sparing GLS2 in normal cells: Blocking EMT (Epithelial-to-Mesenchymal Transition) : These inhibitors can help prevent EMT, which supports cancer spread

Interestingly, a two-cohort study showed that activated HLA-DR high CD11c high CD14 + monocytes were increased in the PBMCs of patients with mild COVID-19, whereas dysfunctional HLA-DR low CD163 high (indicative of anti-inflammatory function) CD14 + monocytes were observed in severe COVID-19 cases

This factor affects the transcription of various genes involved in glucose and lipid metabolism and energy balance, such as fatty acyl-CoA synthase, malic enzyme, glucokinase, and glucose transporter 4 (GLUT4), among others

These infections are mainly attributed to C

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Zeyu Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers