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The albumin acts as a circulating depot, slowly releasing active peptide

The IRB waived the need for written informed consent when it was previously obtained at entry into the SHAVE cohort

As miR-194-3P is responsible for progesterone resistance [119] and apigenin can modulate progesterone receptor [175], hence, future research unveiling the effect of apigenin on miR-194-3P will explain its mechanistic pathway in a better way

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After qPCR quantification using the KAPA library quantification kit (Roche), Sequencing was carried out on the NovaSeq 6000 instrument from Illumina based on a 2 100 cycle mode (paired-end reads, 100 bases) to obtain around 100 million clusters (200 million raw paired-end reads) per sample

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