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2017 Jun 15;12(6):e0179538

A potential explanation for this failure to inhibit GAA production may be inadequate dose or duration of creatine supplementation

ROS and RNS may trigger programmed cell death, e.g., apoptosis [29], necessary for tissue remodeling during the development and normal tissue turnover [30], proliferation, differentiation, maturation of neural stem cells, dendritic processes, and synaptic plasticity [31,32,33]