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Moreover, using conditional knockout mouse models (e.g., chondrocyte-specific Trpv1 / or Slc2a1 / ), the protective effects of CAT on ferroptosis and OA progression in vivo need to be verified, combined with spatial metabolomics to analyze dynamic changes in lipid peroxidation products and antioxidant molecules in joint tissues following CAT intervention

However, the experimental results and the potentially synergistic effect can be strongly dependent on the experimental design

All these events ultimately result in hepatocellular necrosis, although recent studies have also suggested the importance of necroptosis 14,15,16,17,18