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Clinical studies have linked such supplementation to improvements in joint health, including reduced pain and enhanced function, particularly in individuals with osteoarthritis [125]

Natural compounds such as curcumin and gambogenic acid induce ERS-dependent apoptosis by specifically activating the ATF6 and IRE1 pathways [111, 112], while -hederin causes irreversible proteostasis collapse by simultaneously blocking ERAD and autophagic flux [113]

Pharmacologically induced depletion of resident microglia with tamoxifen and diphtheria toxin prior to the induction of ischemic stroke in a mouse model resulted in a decreased infarct volume and levels of pro-inflammatory factors (Li et al., 2021)

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Results The case-control study comprised 294 ALS cases (60.2% men) with a mean age of 65.4 (SD 11.0) years and 504 controls (59.3% men) with a mean age of 66.3 (SD 10.3) years ( Table 1 )