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Liang X, Wang Y, Luo B, Lin B, Lu W, Tian S

The role of Nrf2 in regulating ferroptosis has become increasingly understood, the fully functional Nrf2 maintains cellular iron homeostasis (upregulates ferritin FTH1 and output protein FPN1), ensures antioxidant capacity (activates the System Xc-/GSH/GPX4 axis), and inhibits lipid peroxidation (downregulates ACSL4, etc.) through its transcriptional regulatory network (Zhou et al., 2024)

E., Lee, E

During aging, glutathione levels appear to decline in a number of tissues, thereby putting cells at increased risk of succumbing to stress

Serine can be converted to glycine by SHMT1 in the cytoplasm or SHMT2 in the mitochondria [26,27,28]

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