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A critical initiating event in neuroinflammation is the detection of homeostatic disturbances within the CNS

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Once absorbed, NAC is readily taken up by cells and converted into L-cysteine, which is then rapidly incorporated into the glutathione tripeptide by the enzyme gamma-glutamylcysteine synthetase

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Additionally, alignment to the central helical Z -axis and a simple morph of the global basal and activated models show that the large conformational change is possible in the filament with fewer clashes when the CD moves in concert with the RDs (Supplementary Fig

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