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Protein Biogenesis and Oxidation Canonically, secretory and transmembrane proteins are targeted to the ER membrane by the signal recognition particle (SRP) which recognizes both cleavable N-terminal signal peptides and internal non-cleaved transmembrane domains

The 2025 systematic review in orthopaedic sports medicine looked at 35 animal studies and found no lethal dose across multiple administration routes and a wide dosing range (6 g/kg to 20 mg/kg)

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Intramuscular injection near an injury site (a common self-administration approach) adds a theoretical local concentration benefit that has some support in animal wound models but has not been tested head-to-head against subcutaneous delivery in a controlled trial

0.254.5 mg once weekly, raised in phases over several weeks

International Journal of Dermatology, 64: 992-1004