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Moreover, other specialized mitochondria-residing proteins, such as the apoptosis inducing factor (AIF) and endonuclease G, are translocated to the nuclei following their release from mitochondria and promote peripheral chromatin condensation and high molecular weight DNA fragmentation

However, it is important to note that both THC and CBD have many CBR-independent or indirect signaling mechanisms that also contribute to their overall outcomes (Pertwee, 2008