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J Immunol 173:28596, PMID: 15210786 DAlessio M, De Nicola M, Coppola S, Gualandi G, Pugliese L, Cerella C, Cristofanon S, Civitareale P, Ciriolo MR, Bergamaschi A, Magrini A, Ghibelli L (2005) Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis

This iron-driven oxidative stress sustains chronic inflammation and perpetuates intestinal damage

It is connected at its rear pole to the brain via the optic nerve

S.AlabasterA.BangioloL.HaileA.WinikorJ.et al

[153] has elucidated that the downregulation of hepatic ACSL4 in hepatocytes within a murine model fed a hyperlipidemic diet results in a diminished accumulation of lipids and an exacerbation of insulin resistance

At excessive intracellular copper levels, ATP7A and ATP7B are activated to export excess copper ions from the TGN and sequester them in copper-binding proteins such as metallothionein [40]