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Immunologic encounters and microbial clearance mechanisms, in general, involve phagocytosis with ROS, and clearance by RNS and by apoptosis, while cytokines, such as TNFa, IL-4 and IFNy evoke ROS and RNS, directly and indirectly, via signaling pathways

In contrast, secondary metabolites are compounds that are not needed for life, usually not only possessing a wide range of biological functions but also having special mechanisms of action (Li et al., 2021)