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Antimicrob Agents Chemother 1989;33:1841-4

Context-dependent autoprocessing of human immunodeficiency virus type 1 protease precursors

MTHFR itself is a folate-cycle enzyme, not a B12 enzyme it generates 5-methyltetrahydrofolate, the methyl donor that methionine synthase uses together with methylcobalamin to remethylate homocysteine