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14 Impaired autophagy in aged immune cells leads to the accumulation of damaged mitochondria and protein aggregates, exacerbating oxidative stress and inflammasome activation

2011;63:286294 Bardou-Jacquet E, Laine F, Guggenbuhl P, Morcet J, Jezequel C, Guyader D, et al

These findings suggest that NAC therapy could be valuable in other clinical situations in which GSH deficiency or oxidative stress plays a role in disease pathology, e.g