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3 Once activated by infection, neutrophils are rapidly recruited to sites of inflammation in the lungs, where they produce and secrete cytokines, enzymes, including elastase (NE), reactive oxygen species (ROS) by oxidative burst, and finally release DNA to form neutrophil extracellular traps (NETs)

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doi: 10.3389/fimmu.2024.1470283 21 LarssonSCBurgessS

If formation of adducts occurs at the N-3 or N-7 of Ade, or the N-7 of Gua, the most nucleophilic sites in Ade and Gua [55], destabilization of the glycosyl bond and subsequent depurination of the adduct from DNA takes place [20, 22, 25]

As free copper rises: norepinephrine spikes dopamine destabilizes stress responses surge sensory pathways become hyperreactive This is why copper overload so often shows up as: sudden meltdowns panic with noise emotional storms extreme sensitivity to change ADHD-like hyperreactivity And importantly copper overload directly increases oxidative stress , making it one of the most influential biotypes in ASD