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Mice lacking apoA-I develop autoimmunity when challenged with a high cholesterol (diet and background, Ldlr -/- ), which includes T cell activation and production of autoantibodies (821,822)

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Also, they showed a decrease in FM and an increase in LBM, translating both findings into effects on muscle oxidative enzymes and reduction in body fat (Taaffe et al., 2001)

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On the other hand, cigarette smoke increases free radicals in our body