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confirmed that overexpressed SLC1A3 in gastric cancer activates the PI3K/AKT pathway, upregulates the expression levels of Glucose transporter 1 (GLUT1), Hexokinase 2 (HK2), and Lactate dehydrogenase A (LDHA), and promotes the growth of gastric cancer, while treatment with the PI3K/AKT inhibitor LY294002 could inhibit the growth-promoting effect of SLC1A3 overexpression on gastric cancer

Isocitrate dehydrogenase may be the primary source of NADPH in the cytosol

In contrast, the world health organization (WHO) recommends that levels of Mn do not exceed 30 g/m 3

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93 , 103318 (2019 Garren, M

Hu R, Xie X-Y, Xu S-K, Wang Y-N, Jiang M, Wen L-R, Lai W, Guan L (2017) PM2.5 exposure elicits oxidative stress responses and mitochondrial apoptosis pathway activation in HaCaT keratinocytes