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Int J Mol Med 24(3):319326 Amaral JD, Castro RE, Sola S, Steer CJ, Rodrigues CM (2007) p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis

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However, secondary preventative interventions such as antiplatelet drugs, -blockers, angiotensin-converting-enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), and HMG-CoA reductase inhibitors (statins) have been shown to significantly reduce CVD risk [3]

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From a PPPM perspective, creatine profiling through biofluids, tissue sampling, and advanced imaging (e.g., proton magnetic resonance spectroscopy) offers a minimally invasive approach for early detection, patient stratification, and monitoring of mitochondrial function

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Proline isomerization of histone H3 regulates lysine methylation and gene expression

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The pharmacometabolomic approach provided verification of target engagement when using combined treatment with probenecid and NAC in children with severe TBI

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