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(2) IVs are not affected by confounding factors

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After exposure to electrophilic or oxidative stress, the sensor residues cysteine of Keap1, especially C151, C226, C273, and C288, undergo oxidation and modification, causing conformational changes that inhibit Keap1-mediated NRF2 degradation [94]

Melatonin stimulates the nonamyloidogenic processing of APP through the positive transcriptional regulation of ADAM10 and ADAM17