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1,3,6 Dietary Sources of the Longevity Vitamin Ergothioneine Cognitive decline and neuroprotection Several studies have reported that lower blood concentrations of EGT are consistently associated with a higher prevalence of cognitive impairment and an accelerated rate of cognitive decline in older adults

137 In addition, topical intranasal drug combining tuaminoheptane sulphate (vasoconstrictor) and N-acetylcysteine exhibits a rapid decongestant effect with a significant decrease of resistance and increase of inspiratory flow

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The COLBOS mutation was linked to stronger activation of the canonical reelin target Dab1, and this signaling pathway was shown to directly lead to reduction in tau phosphorylation and amelioration of the phenotype in a mouse model of tauopathy [197]