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Funding DP is supported by the National Multiple Sclerosis Society (RG-1610-26049) and the National Institutes of Health Grants R01 NS102267, R01 NS090464 and R01 NS095562

IRS1/2, Shc, and Grb, are typical adaptors to transduce signaling from IGF-IR to downstream effectors

Treatment with MBE mitigated anhedonia and immobility time observed in mice

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Of note, an ~50-63% reduction in the binding of the WIN-35,428 ligand to dopamine transporter was shown in the caudate region and a 64-75% reduction in the putamen region in patients with LNS (72)