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372 All these astrocytic changes result in considerable and often irreversible neuronal damage, with about 50% of patients demonstrating persistent neurological manifestations even after liver replacement and normalisation of blood ammonium

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71,533,601,602,603,604 Morphological atrophy of astrocytes develops in a brain-region-linked fashion, starting first in the entorhinal and prefrontal cortices (which are, incidentally, the most vulnerable to AD) and then spreading to hippocampus

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DS or trisomy 21, first described by Dr

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