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Niacin (B3): Helps in the production of energy, brain functioning, and skin health

The literature also describes upregulation of growth factors involved in tissue repair, modulation of nitric oxide synthase activity, and effects on the dopaminergic and serotonergic systems that are harder to interpret clinically [Sikiric et al., Inflammopharmacology, 2018]

Hematology 23:653657

In muscles, the spinal cord, and the brain, the liver enzyme glutamine synthetase converts glutamate and ammonia (a toxic byproduct) into glutamine, protecting against ammonia toxicity