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However, the main obstacles to their clinical application are targeting and bioavailability

By tuning the viscosity of condensates (108) and enhancing the adenosine moiety effect to protect protein hydration shells and prevent hydrophobic collapse often associated with amyloid fibrillization and aggregation (107), melatonin may be instrumental for the successful attenuation of AMD progression via the regulation of protein phase separation in the retina under normal and oxidative conditions

doi:10.1016/j.jpsychires.2012.06.008, PMID: 22841833 Gawryluk JW, Wang JF, Andreazza AC, Shao L, Yatham LN, Young LT (2011) Prefrontal cortex glutathione S -transferase levels in patients with bipolar disorder, major depression and schizophrenia

Galms et al

In both reviews, the participants' waist measurements didn't change much