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Because of the potential cognitive side effects associated with the use of diazepam, this medication should be avoided in those patients with SCI who have a concomitant brain injury

24 however, PLMS are also commonly seen in the general population (especially the elderly), 25 in other sleep disorders, such as obstructive sleep apnoea, narcolepsy and REM behaviour disorder, and in non-sleep disorders including Parkinsons disease and other synucleinopathies

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These proteins inhibit apoptosis by binding to and neutralizing pro-apoptotic factors such as Bax and Bak, preventing their oligomerization and subsequent increase in mitochondrial outer membrane permeability, thereby promoting neuronal survival (104)

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